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What is 98% of our DNA?

Genes only make up a small part of the genome, and the rest is composed of intergenic regions that do not code for proteins.

Each of the over 200 cell types in the body interprets this identical information very differently in order to perform the functions necessary to keep us alive. This demonstrates that we need to look beyond the sequence of DNA itself in order to understand how an organism and its cells function.

Epigenetic science

The Science behind Epigenetics

Epigenetics explains how experiences can alter gene activity without interfering with the DNA sequence. It is also responsible for the inheritance of various traits and the ability to transmit these traits over several generations. Many people call this cellular memory.

Previously, it was believed that epigenetic transformations take place only at the initial stage of the formation of an organism and are not observed in adulthood... But everything changed at the end of the 20th century, when a revolution took place in the genetic worldview. It became extremely clear that these changes are constantly occurring and are affecting our lives.

Experiences Affect How Genes Are Expressed | Epixlife

How Experiences Affect Our Gene Expression

One of the most studied mechanisms of epigenetic regulation of gene activity is the process of methylation, which is the addition of a methyl group to cytosine DNA bases.

Methylation is an important process for our genes at different times in our lives, and conditions that interfere with methylation may саuse us harm in the future. For example, during pregnancy it is very important to consume folic acid along with vitamin B12 and the amino acid methionine, which serves as a donor-supplier of methyl groups necessary for the normal flow of methylation, otherwise, it increases the risk of having a baby with pathologies.

As another good example - continuous consumption of green tea reduces the risk of cancer, as it contains a substance called Epigallocatechin gallate (EGCG), which can activate genes that suppress tumor growth demethylating their DNA sites.

Methylation process

Our genetic information is encoded in the letters, or bases, of the DNA sequence. Inside cells, DNA is coiled around proteins called histones. The histone-free DNA allows the genes on it to be turned on. In turn, the genes coiled around the histones are turned off.

One of ways to turn off a certain gene is to attach to it a small methyl group. This implies that the DNMT enzyme binds to DNA and transfers the methyl group to the cytosine base, which is twisted out of the DNA strand (this usually occurs in areas where guanine follows cytosine).

DNA methylation is a process when, under certain environmental conditions, a certain part of genes is turned on or turned on without changing the DNA structure. The gene remains the same, but its expression, in another word, its activity changes.

DNA Methylation | Epixlife
Gene expression | Epixlife

What is Gene Expression?

To better appreciate the goal of Epixlife, it is first helpful to understand what we mean by gene expression. Remember that genes encode the information necessary to make proteins, which are the molecules that perform functions in the cell.  How much protein a given gene ultimately produces, or whether it is allowed to make any at all, is determined by its gene expression or activity.  

If the cell is expending energy to make RNA from DNA, then it is likely being used for something. Proteins that bind to DNA influence whether a gene is expressed, and chemical modifications of DNA can also prevent or enhance gene expression. 

Why do we use Hair as a biomarker?

The functional complexity of hair follicles makes it a perfect source to provide comprehensive results based on your bio-information.

The arrector pili muscle of the hair is constantly sensing not only the changes in temperature and atmospheric pressure but also vibrations and frequencies from the ecosystem and the surrounding area.

It reacts instantly to systems shock and fears, causing the hair to ‘stand on end’ and relaxes when the system is calm. It expands and contracts when the system is overheated or cooled, therefore the cells contained in the hair bulb store the bio-information as it is connected to the arrector pili muscle.

Hair as a biomarker | Epixlife
Epixlife test | Epixlife

What does Epixlife do?

At Epixlife we are dedicated to identifying sequences within the genome that have some type of biochemical activity and identifying nutritional needs or environmental factors that influence the expression of your genes.

Our researchers carried out various techniques on multiple cell types to account for natural variability. We have tested how different nutritional conditions or needs affect gene expression and we are constantly making new investments to find more correlations between environmental, emotional, nutritional factors and the human genome.

Some of our Latest Researches

Epigenetics and Epigenome

Traditionally speaking, epigenetics is the study of changes in gene expression that are not mediated by the DNA sequence...

By Carlos Orozco (BSc, MSc, ND, MD, PhD, FPAMS), 2019

epigenetica epigenoma

Quantum Physics

Reviewing the history and evolution of physics, one finds that as early as 450 BC, Democritus developed the "atomic theory of the universe" in which he...

by Dr. Donado Méndezy and Dr. Carlos Orozco, 2019

fisica quantica

Quantum Mechanics

The Wave Equation, the Personal Identification Wave, and Entanglement by Dr. Carlos Orozco, 2019

mecanica quantica